Connection Establish Between HSV Out Break and Cellular Stress

Once inside the host, the herpes simplex virus remains as a latent infection through out the life of the host.

The DNA genome of HSV is silent during latency.  A connection has now been established between cellular stress and the reactive expression of the genes creating herpes symptoms through infective virus particles.

 “Cliffe et al. report that signaling through the c-Jun N-terminal kinase (JNK) pathway, which is activated in response to various types of cellular stress, relieved transcriptional repression of latent HSV.”

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